Kyler Murray is inactive for Week 6 as the Cardinals face the Colts, with Jacoby Brissett stepping in at quarterback. Arizona shifts to Bam Knight at running back, while Bilal Nichols (personal) and Blake Gillikin (back) are out, and several defenders remain questionable. Brissett's leadership is praised as he embraces a start that tests Arizona’s readiness and game plan execution.

Expect Brissett to lean on a stabilized game plan and a committee-backed rushing approach with Knight, while Zay Jones and the receiving group must prove consistency despite limited practice. The coaching staff emphasizes detail-oriented execution and situational discipline to leverage matches against Indianapolis, shaping the fantasy upside across the Cardinals’ offense this week.

Cardinals place Blake Gillikin out and sign Pat O'Donnell to punt duties as Bilal Nichols is listed as questionable for personal reasons ahead of Sunday's clash with the Colts. If Nichols cannot play, Arizona would need to elevate two defensive linemen from the practice squad to shore up the interior. O'Donnell's punts and hang time will influence field position, making special teams a subtle but real swing factor in this matchup.

Fantasy managers should watch punt opportunities, potential DL promotions, and any last minute roster moves that could affect snaps, tackles, or punt return risk in this week's game against Indianapolis.

Cardinals held a bonus Monday practice after the mini-bye, with five players absent: Benson, Wilson, Campbell, Robinson and Fehoko. Benson is day-to-day; Wilson left with an ankle issue but returned; Robinson chest; Fehoko in concussion protocol; Campbell possibly rested.

Johnson and Jones worked in the open portion, and Nichols had his PUP window opened in anticipation of activation from last year’s neck injury.